2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (294):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-161829
    CDK7 ligand 1
    CDK7 ligand 1 is an active control ligand for CDK7 ligand 2 (HY-161830). CDK7 ligand 2 is a CDK7 ligand. CDK7 ligand 2 can be used in the synthesis of PROTACs.
    CDK7 ligand 1
  • HY-170326
    HSP90-IN-35 1207597-54-3
    Hsp90-in-35 (Compound 379) is an inhibitor of Hsp90. The IC50 of HSP90-IN-35 for Her2 is between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize PROTAC (HY-153881).
    HSP90-IN-35
  • HY-400897
    7α,25-Dihydroxycholesterol intermediate-1 1326612-12-7
    7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs.
    7α,25-Dihydroxycholesterol intermediate-1
  • HY-168283
    HPK1 ligand 2
    HPK1 ligand 2 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). HPK1 ligand 2 can be used for synthesis DD205-291 (HY-168282).
    HPK1 ligand 2
  • HY-168488
    WDR5 ligand 2 2737222-78-3
    WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
    WDR5 ligand 2
  • HY-162946
    Alkyne-P60
    Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).
    Alkyne-P60
  • HY-162973
    PD-L1 ligand 1
    PD-L1 ligand 1 is a PROTAC target protein ligand. PD-L1 ligand 1 can be used as a PD-L1 degrader.
    PD-L1 ligand 1
  • HY-47709
    STING ligand-3 2762552-73-6
    STING ligand-3 is a Ligand for Target Protein for PROTAC activity control. STING ligand-3 can be used to synthesize Anti-inflammatory agent 70 (HY-157570).
    STING ligand-3
  • HY-130845
    AR antagonist 1 1818885-54-9
    AR antagonist 1 (compound 29) is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020).
    AR antagonist 1
  • HY-115729A
    (R)-PROTAC CDK9 ligand-1 2411021-95-7
    (R)-PROTAC CDK9 ligand-1 (Compound 19.4) is a CDK9-targeting degrader that can be used to synthesize PROTAC with antitumor activity.
    (R)-PROTAC CDK9 ligand-1
  • HY-168292
    BTK ligand 9 1709786-35-5
    BTK ligand 9 is a target protein ligand for BTK and can be used to synthesize PROTAC DD-03-171 (HY-122830).
    BTK ligand 9
  • HY-168965
    BTK ligand 15 2668225-98-5
    BTK ligand 15 is the target protein ligand of PROTAC BTK Degrader-13 (HY-168963). PROTAC BTK Degrader-13 can selectively degrade BTK.
    BTK ligand 15
  • HY-W539427
    BRM/BRG1 ligand 1 1893977-70-2
    BRM/BRG1 ligand 1 is a BRM/BRG1 ligand, and can be used for synthesis of PROTAC BRM/BRG1 degrader-1 (HY-168242).
    BRM/BRG1 ligand 1
  • HY-169988
    BRD9 ligand-5 2633634-64-5
    BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B).
    BRD9 ligand-5
  • HY-161931
    Demethyl-RSL3-boc 2375354-07-5
    Demethyl-RSL3-boc is a ligand for target protein for pROTAC.
    Demethyl-RSL3-boc
  • HY-161807
    DENV ligand 1 1628758-48-4
    DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806).
    DENV ligand 1
  • HY-161711
    CBP/p300 ligand 5
    CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia.
    CBP/p300 ligand 5
  • HY-159472
    SMARCA2/4-ligand-1 2411651-36-8
    2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
    SMARCA2/4-ligand-1
  • HY-10997R
    Ibrutinib (Standard) 936563-96-1
    Ibrutinib (Standard) is the analytical standard of Ibrutinib. This product is intended for research and analytical applications. Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.
    Ibrutinib (Standard)
  • HY-176129
    AR ligand 41
    AR ligand 41 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). AR ligand 41 can be used for the synthesis of BWA-6047 (HY-176128).
    AR ligand 41